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1: Bioorg Med Chem. 2004 Aug 1;12(15):4189-96.Click here to read Links

Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants.

Bhandari K, Srivastava S, Shankar G.

Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. bhandarikalpana@rediffmail.com

A series of thiourea derivatives (7-23, 25-27) of 1-aminotetrahydronaphthalene (4) and 1-amino-2-hydroxytetrahydronaphthalene (5) were synthesized in single pot in 48-90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14, 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants.

PMID: 15246095 [PubMed - indexed for MEDLINE]