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Curr Opin Immunol. 2004 Aug;16(4):400-5.

Real-time imaging of T-cell development.

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  • 1Institut National de la Sante et de la Recherche Medicale U277, D├ępartement d'Immunologie, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France. bousso@pasteur.fr


The cellular and molecular dynamics underlying intrathymic T-cell development are still poorly understood. Dynamic imaging techniques offer new opportunities for dissecting the complex journey of developing T cells in the thymus. In particular, two-photon laser scanning microscopy has recently demonstrated great promise in tracking lymphocyte behavior in tissue environments. Resolving thymocyte behavior at the single-cell level should help to clarify the mode of trafficking in the thymus and identify the spatio-temporal aspects of thymic selection events.

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