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    Nature. 2004 Jul 8;430(6996):1 p following 165; discussion 2 p following 165.

    Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

    Tschöp M, Castañeda TR, Joost HG, Thöne-Reineke C, Ortmann S, Klaus S, Hagan MM, Chandler PC, Oswald KD, Benoit SC, Seeley RJ, Kinzig KP, Moran TH, Beck-sickinger AG, Koglin N, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Schindler M, Arndt K, Rudolf K, Mark M, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Craney S, Flora D, Smiley D, Heiman ML.

    Source

    Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA. tschoemh@ucmail.uc.edu

    Erratum in

    • Nature. 2004 Sep 23;431(7007):1038. Withcomb, DC [corrected to Whitcomb, DC].

    Abstract

    Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

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    PMID:
    15243972
    [PubMed - indexed for MEDLINE]

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