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Immunol Allergy Clin North Am. 2004 Aug;24(3):373-97, v-vi.

Immune mechanism of drug hypersensitivity.

Author information

  • Division of Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, University of Bern, 3010-Bern, Switzerland. werner.pichler@insel.ch

Abstract

Drug hypersensitivity reactions can lead to a great variety of different diseases. The main cause is a specific interaction of antibodies or T cells with a drug. In addition to the hapten concept, some drugs can bind directly to T-cell receptors and stimulate them. Based on recent investigation on different exanthemas, an extended classification of the Gell and Coombs type IV reaction is proposed.

PMID:
15242717
[PubMed - indexed for MEDLINE]
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