Trends Mol Med. 2004 Jul;10(7):299-302.

Warfarin and the vitamin K-dependent gamma-carboxylation system.

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Departments of Internal Medicine and Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. rwallin@wfubmc.edu

Abstract

Insight into the molecular basis for genetic warfarin resistance has recently been accomplished by the identification of an 18-kDa protein of the endoplasmic reticulum that is targeted by the drug. When expressed in eukaryotic and insect cells, the protein reduces vitamin K1 2,3-epoxide in a warfarin-sensitive reaction. This finding strongly suggests that the protein is part of the vitamin K cycle, which is essential for the production of vitamin K-dependent proteins. Identification of the 18-kDa protein has aided the understanding of the vitamin K-dependent gamma-carboxylation system at the molecular level.

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