Epithelium-mesenchyme: a balancing act of RhoGAP and RhoGEF

Curr Biol. 2004 Jul 13;14(13):R508-10. doi: 10.1016/j.cub.2004.06.039.

Abstract

Transitions between epithelium and mesenchyme, in either direction, contribute repeatedly to animal development. Three striking papers suggest that distinct components with opposite activities, which together form a complex known for its role in cytokinesis, control these opposite transitions.

Publication types

  • Review
  • Comment

MeSH terms

  • Adherens Junctions / metabolism
  • Animals
  • Caenorhabditis elegans / embryology*
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins / metabolism
  • Cell Division / physiology
  • Cell Movement / physiology
  • Cell Polarity / physiology
  • Drosophila / embryology*
  • Drosophila / metabolism
  • Drosophila Proteins / metabolism
  • Epithelium / embryology
  • GTPase-Activating Proteins / metabolism*
  • Guanine Nucleotide Exchange Factors / metabolism*
  • Kinesins / metabolism
  • Mesoderm / cytology
  • Microtubules / metabolism
  • Models, Biological*
  • Rho Guanine Nucleotide Exchange Factors
  • rho GTP-Binding Proteins / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • Drosophila Proteins
  • GTPase-Activating Proteins
  • Guanine Nucleotide Exchange Factors
  • Pbl protein, Drosophila
  • Rho Guanine Nucleotide Exchange Factors
  • ZEN-4 protein, C elegans
  • rho GTPase-activating protein
  • Kinesins
  • rho GTP-Binding Proteins