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Arch Gen Psychiatry. 2004 Jul;61(7):738-44.

Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder.

Author information

  • 1Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virgoinia Commonwaelth University, Richmond, 23298-0003, USA. dfoley@hsc.vcu.edu

Abstract

BACKGROUND:

Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder.

OBJECTIVE:

To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys.

DESIGN:

Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline.

SETTING:

A community-based sample of twin boys.

PARTICIPANTS:

Five hundred fourteen male twins aged 8 to 17 years.

MAIN OUTCOME MEASURE:

Conduct disorder.

RESULTS:

There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction.

CONCLUSION:

This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.

PMID:
15237086
[PubMed - indexed for MEDLINE]
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