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Lab Anim (NY). 2004 Feb;33(2):26-32.

Virus PCR assay panels: an alternative to the mouse antibody production test.

Author information

  • 1Charles River Laboratories, 251 Ballardvale Street, Wilmington. MA 01887, USA.

Abstract

Antibody production tests have traditionally been used to test biological materials for viral contamination. Now molecular biology techniques have emerged as an alternative. The authors compare MAP testing with PCR-based detection methods, focusing on differences in animal use, laboratory requirements, sample size, and limits of detection.

Comment in

  • PCR and the 3 Rs. [Lab Anim (NY). 2004]
PMID:
15235643
[PubMed - indexed for MEDLINE]
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