J Immunol. 1978 Nov;121(5):1861-4.

Thymic macrophages modulate one stage of T cell differentiation in vitro.

Abstract

We have described a procedure for isolating thymic macrophages and have evaluated their activity in stimulating thymocyte maturation in vitro. The culturing of gradient-purified immature thymocytes on thymic macrophages leads to an increased expression of H-2 antigens and decreased lytic sensitivity with anti-TL and C. The macrophage-stimulated thymocyte also acquires the ability to respond in the MLR. We propose that the macrophage may regulate one stage of thymic differentiation in vivo.

PMID:: 152329; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Supplemental Content

Save items

Related citations in PubMed

Thymic maturation in vitro by a secretory product from macrophages. [J Immunol. 1977]
Thymic maturation in vitro by a secretory product from macrophages.
Beller DI, Unanue ER. J Immunol. 1977 May; 118(5):1780-7.
Macrophage subpopulations regulate intrathymic T-cell development. I: Ia-positive macrophages augment thymocyte proliferation. [Thymus. 1984]
Macrophage subpopulations regulate intrathymic T-cell development. I: Ia-positive macrophages augment thymocyte proliferation.
Zepp F, Schulte-Wissermann H, Mannhardt W. Thymus. 1984; 6(5):279-93.
T cell differentiation/maturation of CD34+ stem cells from HIV-seropositive hemophiliacs in cultured thymic epithelial fragments. [Stem Cells. 1996]
T cell differentiation/maturation of CD34+ stem cells from HIV-seropositive hemophiliacs in cultured thymic epithelial fragments.
Ruiz M, Roodman ST, Bouhasin JD, Knutsen AP. Stem Cells. 1996 Jan; 14(1):132-45.
Review Macrophages in the thymus. [Surv Immunol Res. 1985]
Review Macrophages in the thymus.
Wood GW. Surv Immunol Res. 1985; 4(3):179-91.
Review [Macrophages and the functional differentiation of thymocytes (a review of the authors' own data)]. [Zh Obshch Biol. 1991]
Review [Macrophages and the functional differentiation of thymocytes (a review of the authors' own data)].
Galaktionov VG, Anfalova TV, Semenkova LN, Dudich EI. Zh Obshch Biol. 1991 Jul-Aug; 52(4):564-83.

See reviews... See all...

Cited by 17 PubMed Central articles

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization. [J Exp Med. 1980]
Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization.
Wekerle H, Ketelsen UP, Ernst M. J Exp Med. 1980 Apr 1; 151(4):925-44.
Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice. [J Exp Med. 1981]
Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice.
Jenkinson EJ, Van Ewijk W, Owen JJ. J Exp Med. 1981 Feb 1; 153(2):280-92.
During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen. [Proc Natl Acad Sci U S A. 1980]
During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen.
Lu CY, Beller DI, Unanue ER. Proc Natl Acad Sci U S A. 1980 Mar; 77(3):1597-601.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Thymic macrophages modulate one stage of T cell differentiation in vitro.
Thymic macrophages modulate one stage of T cell differentiation in vitro.
J Immunol. 1978 Nov ;121(5):1861-4.

PubMed
Effects of chlorpromazine and lorazepam on explicit memory, repetition priming a...
Effects of chlorpromazine and lorazepam on explicit memory, repetition priming and cognitive skill learning in healthy volunteers.
Psychopharmacology (Berl). 1992 ;108(3):345-51.

PubMed
Nutritional status and dietary manipulation in predialysis chronic renal failure...
Nutritional status and dietary manipulation in predialysis chronic renal failure patients.
J Ren Nutr. 2004 Jul ;14(3):127-33.

PubMed
Rebound insomnia and newer hypnotics.
Rebound insomnia and newer hypnotics.
Psychopharmacology (Berl). 1992 ;108(3):248-55.

PubMed
The effects of a combined strength and aerobic exercise program on glucose contr...
The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes.
Eur J Appl Physiol. 2004 Aug ;92(4-5):437-42.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Thymic macrophages modulate one stage of T cell differentiation in vitro.

Abstract

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 17 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information