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Genes Dev. 2004 Jul 1;18(13):1527-32.

Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.

Author information

  • 1Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. k.poss@cellbio.duke.edu

Abstract

Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.

PMID:
15231734
[PubMed - indexed for MEDLINE]
PMCID:
PMC443515
Free PMC Article
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