Ageing Res Rev. 2004 Jul;3(3):355-67.

The iron-heart disease connection: is it dead or just hiding?

Source

Mineral Bioavailability Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. richard.wood@tufts.edu

Abstract

More than 20 years ago it was proposed that differences in body iron stores may account for differential heart disease prevalence in men and women. In 1992 Finnish investigators presented intriguing supportive evidence for this proposal by showing that middle-aged men with normal but elevated serum ferritin, a biomarker of body iron stores, were at increased risk for acute myocardial infarction. During the past dozen years many studies have followed leading to intense debate on the role of iron in the development of heart disease. A meta-analysis of prospective studies found, however, no support for the iron-heart disease hypothesis. As new disease associations with iron status continue to be explored, consideration needs to be given to the lessons learned from these studies. Moreover, additional efforts need to be made to find a simple, high throughput and more satisfactory measure of the forms of iron in the body that are liable to do damage.

PMID:: 15231242; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

IRON - HSDB

Supplemental Content

Save items

Related citations in PubMed

Excessive body iron stores are not associated with risk of coronary heart disease in women. [J Nutr. 2008]
Excessive body iron stores are not associated with risk of coronary heart disease in women.
Sun Q, Ma J, Rifai N, Franco OH, Rexrode KM, Hu FB. J Nutr. 2008 Dec; 138(12):2436-41.
Review Iron and heart disease: the epidemiologic data. [Nutr Rev. 1996]
Review Iron and heart disease: the epidemiologic data.
Sempos CT, Looker AC, Gillum RF. Nutr Rev. 1996 Mar; 54(3):73-84.
Increased levels of serum transferrin receptor and serum transferrin receptor/log ferritin ratios in men with prostate cancer and the implications for body-iron stores. [J Lab Clin Med. 2004]
Increased levels of serum transferrin receptor and serum transferrin receptor/log ferritin ratios in men with prostate cancer and the implications for body-iron stores.
Kuvibidila S, Gauthier T, Warrier RP, Rayford W. J Lab Clin Med. 2004 Oct; 144(4):176-82.
Review Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis. [Cancer Causes Control. 2007]
Review Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis.
Kabat GC, Rohan TE. Cancer Causes Control. 2007 Dec; 18(10):1047-53. Epub 2007 Sep 6.
Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials. [Am J Clin Nutr. 2008]
Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials.
Yang Z, Dewey KG, Lönnerdal B, Hernell O, Chaparro C, Adu-Afarwuah S, McLean ED, Cohen RJ, Domellöf M, Allen LH, et al. Am J Clin Nutr. 2008 Jun; 87(6):1892-8.

See reviews... See all...

Cited by 2 PubMed Central articles

Excessive body iron stores are not associated with risk of coronary heart disease in women. [J Nutr. 2008]
Excessive body iron stores are not associated with risk of coronary heart disease in women.
Sun Q, Ma J, Rifai N, Franco OH, Rexrode KM, Hu FB. J Nutr. 2008 Dec; 138(12):2436-41.
Iron accumulation with age, oxidative stress and functional decline. [PLoS One. 2008]
Iron accumulation with age, oxidative stress and functional decline.
Xu J, Knutson MD, Carter CS, Leeuwenburgh C. PLoS One. 2008 Aug 6; 3(8):e2865. Epub 2008 Aug 6.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The iron-heart disease connection: is it dead or just hiding?
The iron-heart disease connection: is it dead or just hiding?
Ageing Res Rev. 2004 Jul ;3(3):355-67.

PubMed
Psychiatric rehospitalization of the severely mentally ill: patient and staff pe...
Psychiatric rehospitalization of the severely mentally ill: patient and staff perspectives.
Nurs Res. 1992 Sep-Oct ;41(5):301-5.

PubMed
After the Master Settlement Agreement: trends in the American tobacco retail env...
After the Master Settlement Agreement: trends in the American tobacco retail environment from 1999 to 2002.
Health Promot Pract. 2004 Jul ;5(3 Suppl):99S-110S.

PubMed
Infectious disease risks from dead bodies following natural disasters.
Infectious disease risks from dead bodies following natural disasters.
Rev Panam Salud Publica. 2004 May ;15(5):307-12.

PubMed
Short-term exposure of high glucose concentration induces generation of reactive...
Short-term exposure of high glucose concentration induces generation of reactive oxygen species in endothelial cells: implication for the oxidative stress associated with postprandial hyperglycemia.
Redox Rep. 2004 ;9(2):111-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The iron-heart disease connection: is it dead or just hiding?

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information