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    Lupus. 2004;13(5):317-22.

    A therapeutic role for BLyS antagonists.

    Stohl W.

    Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA. stohl@usc.edu

    B lymphocyte stimulator (BLyS) is a vital B cell survival factor. Overexpression of BLyS in mice may lead to systemic lupus erythematosus (SLE)-like disease, and treatment of bona fide SLE mice with BLyS antagonists ameliorates disease progression and enhances survival. BLyS overexpression is common in human SLE, and results from a phase I clinical trial with a BLyS antagonist in human SLE have shown the antagonist to be biologically active and safe. These features collectively point to BLyS as an attractive therapeutic target in human disease.

    PMID: 15230285 [PubMed - indexed for MEDLINE]

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