Clin Infect Dis. 2004 Jun 15;38(12):1771-9. Epub 2004 May 25.

Highly active antiretroviral therapy and viral response in HIV type 2 infection.

Mullins C, Eisen G, Popper S, Dieng Sarr A, Sankale JL, Berger JJ, Wright SB, Chang HR, Coste G, Cooley TP, Rice P, Skolnik PR, Sullivan M, Kanki PJ.

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Department of Immunology and Infectious Diseases, Harvard University School of Public Health, Boston, Massachusetts 02115, USA.

Abstract

Human immunodeficiency virus type 2 (HIV-2), the second human retrovirus known to cause AIDS, is endemic to West Africa but is infrequently found outside this region. We present a case series of 10 HIV-2--infected individuals treated in the United States. Physicians applied the principles of highly active antiretroviral therapy (HAART), normally used in treating HIV type 1, with modifications considered appropriate for treating HIV-2. CD4+ cell count, HIV-2 virus load, and clinical status were found to correlate well, providing evidence that HIV-2 virus load is useful in managing treatment of patients with HIV-2 who are receiving therapy. However, HAART regimens with predicted efficacy for treatment of HIV type 1 infection are not as efficacious for treatment of HIV-2. Controlled clinical trials of HIV-2-infected patients receiving various HAART regimens are needed to provide therapeutic guidance to the medical community.

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Clin Infect Dis. 2004 Nov 15;39(10):1553-4; author reply 1554.

PMID:: 15227626; [PubMed - indexed for MEDLINE]

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