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Kardiol Pol. 2004 Apr;60(4):335-41.

Biochemical markers of myocardial damage after radiofrequency ablation.

[Article in English, Polish]

Author information

  • 1Department of Electrocardiology, Institute of Cardiology, Collegium Medicum, Jagiellonian University, Cracow, Poland.



Radiofrequency catheter ablation (RFCA) may cause myocardial injury.


To assess changes in myocardial enzymes levels following RFCA.


Creatine kinase (CK), CK-MB, aspartate aminotransferase (GOT), alanine aminotransferase (GPT), troponin I and myoglobin levels were assessed in 53 patients (33 females, 20 males, mean age 53 years, range 23-78 years) before and 20 hours after successful RFCA (WPW type A = 13, WPW type B = 10, atrio-ventricular nodal tachycardia n = 17, atrial fibrillation or flutter n = 5, atrial tachycardia n = 2 and complex arrhythmias n = 6).


The mean number of RF applications was 10.4, cumulative energy - 22 671 J, duration of application - 468 sec, and temperature - 58 degrees C. A significant post-RFCA increase in the troponin I and myoglobin levels was found whereas the changes in CK and GOT levels were less pronounced. A significant correlation between troponin I elevation and RFCA energy, particularly in males, was documented. There was a trend towards a decrease in the GPT and CK-MB levels. Troponin I and myoglobin levels increased regardless of the site of RF energy application.


Troponin I and myoglobin are useful for the assessment of RFCA-induced myocardial injury, regardless of the site of RFCA application.

[PubMed - indexed for MEDLINE]
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