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Aliment Pharmacol Ther. 2004 Jul 1;20(1):23-8.

Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial.

Author information

  • 1Section of Gastroenterology and Hepatology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA. snair@ochsner.org

Abstract

BACKGROUND:

Insulin sensitizing agents may be useful in treatment of non-alcoholic fatty liver disease.

AIM:

A pilot study to evaluate the efficacy and safety of metformin in non-alcoholic fatty liver disease.

METHODS:

In an open labelled study, patients with histologically confirmed non-alcoholic fatty liver disease were given metformin (20 mg/kg) for 1 year. Insulin resistance (by log homeostasis assessment model analysis for insulin resistance and Quantitative Insulin Sensitivity Check Index) and post-treatment hepatic histology were compared with pre-treatment histology.

RESULTS:

Fifteen patients completed 1 year of treatment. During the initial 3 months, there was improvement in alanine aminotransferase and aspartate aminotransferase (P-value 0.01 and 0.02, respectively) along with improvement in insulin sensitivity. However, after 3 months, there was no further improvement in insulin sensitivity and there was gradual rise in aspartate aminotransferase and alanine aminotransferase back to pre-treatment levels. Among the 10 patients with post-treatment biopsy, three (33%), showed improvement in steatosis, two (20%) showed improvement in inflammation score and one (10%) showed improvement in fibrosis.

CONCLUSION:

Metformin treatment was associated with only a transient improvement in liver chemistries. A progressive, sustainable reduction in insulin sensitivity was not noted during treatment.

PMID:
15225167
[PubMed - indexed for MEDLINE]
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