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Med Res Rev. 2004 Sep;24(5):621-38.

Bionanotechnology based on silica nanoparticles.

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  • 1Center for Research at the Bio/nano Interface, Department of Chemistry, University of Florida, Gainesville 32611, USA.


We have developed uniform core/shell nanoparticles, consisting of a silica layer coating and pigments or magnetite core, using a water-in-oil microemulsion method. The nanoparticles are highly luminescent and photostable with the size ranging from 5 nm to 400 nm. Bioconjugation of these silica nanoparticles adds unique biofunctions with various molecules such as enzymes, antibodies, and DNA molecules. Significant advantages have been shown in using bioconjugated nanoparticles for biosensing and bioimaging, such as cell staining, DNA detection and separation, rapid single bacterium detection, and biotechnological application in DNA protection.

Copyright 2004 Wiley Periodicals, Inc.

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