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J Virol. 2004 Jul;78(14):7852-60.

Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen.

Author information

  • 1Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA.

Abstract

Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins. Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity.

PMID:
15220463
[PubMed - indexed for MEDLINE]
PMCID:
PMC434102
Free PMC Article

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