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J Virol. 2004 Jul;78(14):7839-42.

A human cellular protein activity (OF-1), which binds herpes simplex virus type 1 origin, contains the Ku70/Ku80 heterodimer.

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  • 1Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.

Abstract

In an effort to identify host proteins involved in herpes simplex virus type 1 replication, monkey and human cellular protein activities (called OF-1) that bind the viral replication origin, oriS, have been described. We show by mass spectrometry that the DNA-binding component of human OF-1 contains Ku70 and Ku80 proteins.

PMID:
15220460
[PubMed - indexed for MEDLINE]
PMCID:
PMC434072
Free PMC Article
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