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1: Cell Commun Signal. 2004 Jun 25;2(1):5.Click here to read Click here to read Links

Mitogen Activated Protein kinase signal transduction pathways in the prostate.

Maroni PD, Koul S, Meacham RB, Koul HK.

Signal Transduction and Molecular Biology Laboratory, Division of Urology, Department of Surgery, University of Colorado School of Medicine, 4200 East Ninth Avenue, C-319, Denver, CO 80262, USA. hari.koul@uchsc.edu

The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease. We reviewed articles examining mitogen-activated protein kinases using prostate tissue or cell lines. As with other tissue types, these signaling modules are links/transmitters for important pathways in prostate cells that can result in cellular survival or apoptosis. While the activation of the ERK pathway appears to primarily result in survival, the roles of JNK and p38 are less clear. Manipulation of these pathways could have important implications for the treatment of prostate cancer and benign prostatic hypertrophy.

PMID: 15219238 [PubMed - as supplied by publisher]

PMCID: PMC449737