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Fertil Steril. 1992 Sep;58(3):487-91.

Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations.

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  • 1University of Oslo, Norway.

Abstract

OBJECTIVE:

To investigate the impact of body weight (BW) and insulin levels on gonadotropin and androgen levels in women with the polycystic ovarian syndrome (PCOS).

DESIGN:

Comparative study of endocrinologic parameters in PCOS women.

SETTING:

University Hospital Reproductive Endocrinology Unit.

PATIENTS:

Thirty obese and 19 nonobese women with PCOS. Seven obese and 7 nonobese normal women.

MAIN OUTCOME MEASURES:

Serum concentrations of insulin, testosterone, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone. Serum LH response to gonadotropin-releasing hormone (GnRH) administration and assessment of insulin resistance by the continuous infusion of glucose with model assessment (CIGMA) test.

RESULTS:

Fasting insulin levels correlated with body mass index (BMI). Basal LH levels correlated inversely with BMI. Nonobese women with PCOS had a higher LH response to GnRH than obese women with PCOS. Only obese women with PCOS showed insulin resistance and fasting hyperinsulinemia.

CONCLUSIONS:

The data suggest that women with PCOS may be divided into two subgroups: those with obesity, insulin resistance, hyperinsulinemia, and normal/minimally elevated LH levels and those with normal BW, elevated LH levels, and normoinsulinemia.

PMID:
1521640
[PubMed - indexed for MEDLINE]
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