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Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W624-7.

CSTminer: a web tool for the identification of coding and noncoding conserved sequence tags through cross-species genome comparison.

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  • 1Consorzio Interuniversitario per le Applicazioni di Supercalcolo per Universit√† e Ricerca, CASPUR, Rome, Italy.

Abstract

The identification and characterization of genome tracts that are highly conserved across species during evolution may contribute significantly to the functional annotation of whole-genome sequences. Indeed, such sequences are likely to correspond to known or unknown coding exons or regulatory motifs. Here, we present a web server implementing a previously developed algorithm that, by comparing user-submitted genome sequences, is able to identify statistically significant conserved blocks and assess their coding or noncoding nature through the measure of a coding potential score. The web tool, available at http://www.caspur.it/CSTminer/, is dynamically interconnected with the Ensembl genome resources and produces a graphical output showing a map of detected conserved sequences and annotated gene features.

PMID:
15215464
[PubMed - indexed for MEDLINE]
PMCID:
PMC441624
Free PMC Article

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