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Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W309-12.

AUGUSTUS: a web server for gene finding in eukaryotes.

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  • 1University of Göttingen, Institut für Mikrobiologie und Genetik, Goldschmidtstrasse 1, 37077 Göttingen, Germany. mstanke@gwdg.de


We present a www server for AUGUSTUS, a novel software program for ab initio gene prediction in eukaryotic genomic sequences. Our method is based on a generalized Hidden Markov Model with a new method for modeling the intron length distribution. This method allows approximation of the true intron length distribution more accurately than do existing programs. For genomic sequence data from human and Drosophila melanogaster, the accuracy of AUGUSTUS is superior to existing gene-finding approaches. The advantage of our program becomes apparent especially for larger input sequences containing more than one gene. The server is available at http://augustus.gobics.de.

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