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Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice.
Yalcin B,
Fullerton J,
Miller S,
Keays DA,
Brady S,
Bhomra A,
Jefferson A,
Volpi E,
Copley RR,
Flint J,
Mott R.
Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.
Investigation of sequence variation in common inbred mouse strains has revealed a segmented pattern in which regions of high and low variant density are intermixed. Furthermore, it has been suggested that allelic strain distribution patterns also occur in well defined blocks and consequently could be used to map quantitative trait loci (QTL) in comparisons between inbred strains. We report a detailed analysis of polymorphism distribution in multiple inbred mouse strains over a 4.8-megabase region containing a QTL influencing anxiety. Our analysis indicates that it is only partly true that the genomes of inbred strains exist as a patchwork of segments of sequence identity and difference. We show that the definition of haplotype blocks is not robust and that methods for QTL mapping may fail if they assume a simple block-like structure.
PMID: 15210992 [PubMed - indexed for MEDLINE]
PMCID: PMC470780
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Cited by 19 PubMed Central articles
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Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse.
Trachtulec Z, Vlcek C, Mihola O, Gregorova S, Fotopulosova V, Forejt J.
Genetics. 2008 Mar; 178(3):1777-84. Epub 2008 Feb 3.
[Genetics. 2008]
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Nucleotide variation in wild and inbred mice.
Salcedo T, Geraldes A, Nachman MW.
Genetics. 2007 Dec; 177(4):2277-91.
[Genetics. 2007]
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Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes.
Vadasz C, Smiley JF, Figarsky K, Saito M, Toth R, Gyetvai BM, Oros M, Kovacs KK, Mohan P, Wang R.
Neuroscience. 2007 Nov 9; 149(3):561-72. Epub 2007 Jul 17.
[Neuroscience. 2007]
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