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1: Am J Med. 2004 Jul 1;117(1):39-50.Click here to read Links

The antineutrophil cytoplasmic antibody-associated vasculitides.

Seo P, Stone JH.

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome are small- to medium-vessel vasculitides linked by overlapping pathology and the presence of antineutrophil cytoplasmic antibodies (ANCA). Commonly referred to as the ANCA-associated vasculitides, these diseases are challenging to diagnose and to treat. Distinguishing the ANCA-associated vasculitides from other forms of vasculitis or nonvasculitic processes (such as infection) can be particularly difficult. This review describes the clinical and pathologic hallmarks of the ANCA-associated vasculitides, discusses the role of ANCA assays in diagnosis and treatment, and outlines an approach to the evaluation and management of these diseases.

PMID: 15210387 [PubMed - indexed for MEDLINE]

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