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Nat Neurosci. 2004 Jul;7(7):699-700. Epub 2004 Jun 20.

Mpdz is a quantitative trait gene for drug withdrawal seizures.

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  • 1Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health & Science University, and the Department of Veterans Affairs Medical Center, 3181 SW Sam Jackson Park Road, mailcode L-470, Portland, Oregon 97239-3098, USA.


Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.

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