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Bioinformatics. 2004 Dec 12;20(18):3636-7. Epub 2004 Jun 16.

Breakpoint identification and smoothing of array comparative genomic hybridization data.

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  • 1Faculty of Sciences, Vrije Universiteit, De Boelelaan 1117, Amsterdam 1081HV, The Netherlands. <>



We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data.


aCGH-Smooth is free for researchers at academic and non-profit institutions at

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