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Curr Opin Cell Biol. 2004 Apr;16(2):174-81.

The WASP-Arp2/3 pathway: genetic insights.

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  • 1Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, Transcription Laboratory, London, WC2A 3PX, UK.

Abstract

Arp2/3 complex nucleates the formation of dendritic actin filament arrays, which are especially prominent at the leading edges of motile cells. Recent genetic and other loss-of-function studies have highlighted the importance of the Arp2/3 complex for normal cell functions, and especially for cell motility. WASP/Scar family proteins regulate the activity of the Arp2/3 complex, and also link it to several signaling pathways. Recent studies suggest that Scar is a more important regulator of Arp2/3 activity in actin-dependent morphological processes than WASP, which may have a more restricted role in specialized cellular events. It has also become clear that precise regulation of both Scar and WASP activity is of the utmost importance for their physiological functions.

PMID:
15196561
[PubMed - indexed for MEDLINE]
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