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    Cancer Cell. 2004 Jun;5(6):587-96.

    TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

    O'Neil J, Shank J, Cusson N, Murre C, Kelliher M.

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    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

    Abstract

    Activation of the basic-helix-loop-helix (bHLH) gene TAL1 (or SCL) is a frequent gain-of-function mutation in T cell acute lymphoblastic leukemia (T-ALL). To provide genetic evidence that tal1/scl induces leukemia by interfering with E47 and HEB, we expressed tal1/scl in an E2A or HEB heterozygous background. These mice exhibit disease acceleration and perturbed thymocyte development due to repression of E47/HEB target genes. In tal1/scl thymocytes, we find the corepressor mSin3A bound to the CD4 enhancer, whereas an E47/HEB/p300 complex is detected in wild-type thymocytes. Furthermore, tal1/scl tumors are sensitive to pharmacologic inhibition of HDAC and undergo apoptosis. These data demonstrate that tal1/scl induces leukemia by repressing E47/HEB and suggest that HDAC inhibitors may prove efficacious in T-ALL patients who express TAL1/SCL.

    PMID:
    15193261
    [PubMed - indexed for MEDLINE]

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