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Cell Cycle. 2004 Jul;3(7):850-2. Epub 2004 Jul 14.

Don't skip the G1 phase: how APC/CCdh1 keeps SCFSKP2 in check.

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  • 1New York University School of Medicine, New York University Cancer Institute, New York, New York 10016, USA.


By keeping the levels of Skp2 and Cks1 low during G(1) progression, APC/C(Cdh1) prevents unscheduled degradation of SCF(Skp2) substrates and premature entry into S phase. Thus, APC/C(Cdh1), a ubiquitin ligase involved in mitotic exit and maintenance of G(0)/G(1) phase, directly controls SCF(Skp2), a ubiquitin ligase involved in the regulation of S phase entry.

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