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Cell Cycle. 2004 Jul;3(7):850-2. Epub 2004 Jul 14.

Don't skip the G1 phase: how APC/CCdh1 keeps SCFSKP2 in check.

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  • 1New York University School of Medicine, New York University Cancer Institute, New York, New York 10016, USA.

Abstract

By keeping the levels of Skp2 and Cks1 low during G(1) progression, APC/C(Cdh1) prevents unscheduled degradation of SCF(Skp2) substrates and premature entry into S phase. Thus, APC/C(Cdh1), a ubiquitin ligase involved in mitotic exit and maintenance of G(0)/G(1) phase, directly controls SCF(Skp2), a ubiquitin ligase involved in the regulation of S phase entry.

PMID:
15190201
[PubMed - indexed for MEDLINE]
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