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J Antimicrob Chemother. 2004 Jul;54(1):243-6. Epub 2004 Jun 9.

In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites.

Author information

  • 1Institute of Medical Microbiology and Virology, University Hospital Schleswig-Holstein, Campus Kiel, Brunswiker Str. 4, 24105 Kiel, Germany. r.krausse@medmicrobio.uni-kiel.de

Abstract

OBJECTIVES:

To investigate the in vitro activity of Extractum liquiritiae (EL), glycyrrhizic acid (GL), glycyrrhetinic acid (GA) and a novel lipophilic derivative of glycyrrhetinic acid monoglucuronide (GAMG), acetylated GAMG (aGAMG), against 29 Helicobacter pylori strains.

METHODS:

The MIC of each compound was determined by the agar dilution method, and the killing kinetics were monitored in brain heart infusion broth ( approximately 10(6)-10(7) cfu/mL) at 0, 4, 24, 48, 72 and 96 h.

RESULTS:

GA was the most potent compound (MIC(50 /90), 50/100 mg/L), inhibiting 79.3% of the strains at MIC < or =50 mg/L. Clarithromycin-resistant strains were susceptible at 12.5 and 25 mg/L, and metronidazole-resistant strains at 25-50 and at 200 mg/L. The MIC distribution (mg/L) of aGAMG was < or =6.25 (29.2%), 50 (4.2%), 100-200 (12.5%) and > or =400 (54.1%). EL and GL were less active (MICs >400 mg/L). GA exhibited rapid, concentration and strain-dependent bactericidal activity.

CONCLUSIONS:

The potent in vitro activity of GA against H. pylori provides a further explanation for its beneficial effect on peptic ulcers. Its effectiveness against clarithromycin-resistant strains provides hope that it can form the basis for an alternative therapeutic agent against H. pylori.

PMID:
15190039
[PubMed - indexed for MEDLINE]
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