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Chest. 2004 Jun;125(6):2005-10.

Breath condensate pH in children with cystic fibrosis and asthma: a new noninvasive marker of airway inflammation?

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  • 1Department of Thoracic Medicine, National Heart & Lung Institute, Imperial College, London, UK.

Abstract

STUDY OBJECTIVES:

The noninvasive assessment and monitoring of airway inflammation could be important in respiratory disease. The pH of exhaled breath condensate (EBC) is a promising marker. Although pH has been measured in the EBC of adults with inflammatory airway diseases, no study has measured this in children.

DESIGN:

This study aimed to assess whether there is a change in pH in the EBC of children with cystic fibrosis (CF) and asthma, and to try to determine whether pH could be used as a marker of airway inflammation. Furthermore, the relationships among EBC pH, severity of disease, and oxidative stress were studied.

PATIENTS AND METHODS:

We studied 20 children with CF (mean [+/- SEM] age, 7 +/- 3 years), 20 children with asthma (mean age, 7 +/- 2 years), and 15 age-matched healthy children (mean age, 7 +/- 2 years). The pH of EBC was measured using a pH meter.

MEASUREMENTS AND RESULTS:

Lower pH values were observed in the EBC of children with CF and asthma compared to control subjects (mean pH, 7.23 +/- 0.03 and 7.42 +/- 0.01 vs 7.85 +/- 0.02, respectively). Furthermore, relationships among EBC pH, severity of asthma, and the presence of an infective exacerbation of CF was found. There was a negative correlation between exhaled pH and exhaled leukotriene B(4) concentrations (r = -0.5; p < 0.005).

CONCLUSION:

We conclude that the measurement of EBC pH may be useful in the evaluation of airway inflammation in children with asthma and CF.

PMID:
15189915
[PubMed - indexed for MEDLINE]
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