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Annu Rev Nutr. 2004;24:579-96.

Identification of trace element-containing proteins in genomic databases.

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  • 1Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588-0664, USA. vgladyshev1@unl.edu


Development of bioinformatics tools provided researchers with the ability to identify full sets of trace element-containing proteins in organisms for which complete genomic sequences are available. Recently, independent bioinformatics methods were used to identify all, or almost all, genes encoding selenocysteine-containing proteins in human, mouse, and Drosophila genomes, characterizing entire selenoproteomes in these organisms. It also should be possible to search for entire sets of other trace element-associated proteins, such as metal-containing proteins, although methods for their identification are still in development.

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