Br J Cancer. 2004 Jul 19;91(2):355-8.

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.

Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, Flanagan A, Teague J, Futreal PA, Stratton MR, Wooster R.

Source

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

Abstract

The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.

PMID:: 15188009; [PubMed - indexed for MEDLINE]
PMCID:: PMC2409828

Free PMC Article

Images from this publication.See all images (1)Free text

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

PubReader: Say goodbye to the old way of reading articles.

Related citations in PubMed

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. [Nucleic Acids Res. 2011]
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer.
Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, Jia M, Shepherd R, Leung K, Menzies A, et al. Nucleic Acids Res. 2011 Jan; 39(Database issue):D945-50. Epub 2010 Oct 15.
RAS/RAF mutation and defective DNA mismatch repair in endometrial cancers. [Am J Obstet Gynecol. 2004]
RAS/RAF mutation and defective DNA mismatch repair in endometrial cancers.
Mutch DG, Powell MA, Mallon MA, Goodfellow PJ. Am J Obstet Gynecol. 2004 Apr; 190(4):935-42.
Mutations of BRAF and KRAS2 in the development of Barrett's adenocarcinoma. [Oncogene. 2004]
Mutations of BRAF and KRAS2 in the development of Barrett's adenocarcinoma.
Sommerer F, Vieth M, Markwarth A, Röhrich K, Vomschloss S, May A, Ell C, Stolte M, Hengge UR, Wittekind C, et al. Oncogene. 2004 Jan 15; 23(2):554-8.
Review Raf proteins and cancer: B-Raf is identified as a mutational target. [Biochim Biophys Acta. 2003]
Review Raf proteins and cancer: B-Raf is identified as a mutational target.
Mercer KE, Pritchard CA. Biochim Biophys Acta. 2003 Jun 5; 1653(1):25-40.
Review MutationView/KMcancerDB: a database for cancer gene mutations. [Cancer Sci. 2007]
Review MutationView/KMcancerDB: a database for cancer gene mutations.
Shimizu N, Ohtsubo M, Minoshima S. Cancer Sci. 2007 Mar; 98(3):259-67. Epub 2007 Jan 12.

See reviews... See all...

Cited by over 100 PubMed Central articles

A Novel Fully Automated Molecular Diagnostic System (AMDS) for Colorectal Cancer Mutation Detection. [PLoS One. 2013]
A Novel Fully Automated Molecular Diagnostic System (AMDS) for Colorectal Cancer Mutation Detection.
Kitano S, Myers J, Nakamura J, Yamane A, Yamashita M, Nakayama M, Tsukahara Y, Ushida H, Liu W, Ratain MJ, et al. PLoS One. 2013; 8(5):e62989. Epub 2013 May 9.
Distinct types of disorder in the human proteome: functional implications for alternative splicing. [PLoS Comput Biol. 2013]
Distinct types of disorder in the human proteome: functional implications for alternative splicing.
Colak R, Kim T, Michaut M, Sun M, Irimia M, Bellay J, Myers CL, Blencowe BJ, Kim PM. PLoS Comput Biol. 2013 Apr; 9(4):e1003030. Epub 2013 Apr 25.
Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer. [Proc Natl Acad Sci U S A. 2013]
Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer.
Volinia S, Croce CM. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7413-7. Epub 2013 Apr 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.
Br J Cancer. 2004 Jul 19 ;91(2):355-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: