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J Womens Health (Larchmt). 2004 May;13(4):427-30.

Estrogen bioassay of ginseng extract and ArginMax, a nutritional supplement for the enhancement of female sexual function.

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  • 1Department of Gynecology/Obstetrics, Stanford University School of Medicine, Stanford, California, USA.



To determine whether ArginMax (The Daily Wellness Co., Sunnyvale, CA) or the Panax ginseng extract it contains has any estrogenic activity. ArginMax for Women, a nutritional supplement for optimization of sexual health, contains L-arginine, ginseng, ginkgo, damiana, multivitamins, and minerals.


A human endometrial adenocarcinoma cell line, Ishikawa, which contains an alkaline phosphatase (AP) enzyme sensitive to estrogen stimulation, was used in a bioassay to determine whether Panax ginseng or ArginMax contained estrogenic components.


Neither ArginMax nor Panax ginseng stimulated AP at any of the concentrations tested.


No estrogenic activity was evident in the sample of Panax ginseng extract tested or in a sample of ArginMax containing this extract in combination with other ingredients.

[PubMed - indexed for MEDLINE]
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