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Genome Biol. 2004;5(6):R42. Epub 2004 May 18.

Microarray-based genomic surveying of gene polymorphisms in Chlamydia trachomatis.

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  • 1Program in Infectious Diseases, University of California, Berkeley, CA 94720-7360, USA.

Abstract

By comparing two fully sequenced genomes of Chlamydia trachomatis using competitive hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes. Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array analysis and verified by DNA sequencing. These genes may be crucial for understanding chlamydial virulence and pathogenesis.

PMID:
15186493
[PubMed - indexed for MEDLINE]
PMCID:
PMC463075
Free PMC Article

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