Microarray-based genomic surveying of gene polymor...[Genome Biol. 2004]

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1: Genome Biol. 2004;5(6):R42. Epub 2004 May 18. Links

Microarray-based genomic surveying of gene polymorphisms in Chlamydia trachomatis.

Brunelle BW, Nicholson TL, Stephens RS.

Program in Infectious Diseases, University of California, Berkeley, CA 94720-7360, USA.

By comparing two fully sequenced genomes of Chlamydia trachomatis using competitive hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes. Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array analysis and verified by DNA sequencing. These genes may be crucial for understanding chlamydial virulence and pathogenesis.

PMID: 15186493 [PubMed - indexed for MEDLINE]

PMCID: PMC463075

Microarray-based approach for genome-wide survey of nucleotide polymorphisms.
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[Cell Microbiol. 2001]
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Cited by 9 PubMed Central articles

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