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Clin Perinatol. 2004 Mar;31(1):129-42.

Recombinant erythropoietin as a neuroprotective treatment: in vitro and in vivo models.

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  • 1Division of Neonatology, Department of Pediatrics, University of Washington, PO Box 356320, Seattle, WA 98195, USA.


The biologic effects of erythropoietin in the central and peripheral nervous system involve the activation of its specific cell surface receptor and corresponding signal transduction pathways. This article reviews the neuroprotective effects of erythropoietin in brain, emphasizing the progress made using in vitro and in vivo research models.

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