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Protein Pept Lett. 2004 Jun;11(3):271-9.

Alpha-synuclein aggregation.

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  • 1University of Arkansas for Medical Sciences, Donald W. Reynolds Center on Aging, Little Rock, AR 72205, USA.


Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.

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