Format

Send to:

Choose Destination
See comment in PubMed Commons below

Chemokines and chemokine receptors as targets in the therapy of psoriasis.

Author information

  • 1Dept. of Dermatology, Heinrich-Heine-University, Moorenstr. 5, 40225 Düsseldorf, Germany. Bernhard.Homey@uni-duesseldorf.de

Abstract

Chemokines are members of a superfamily of small, cytokine-like, chemotactic proteins that have recently been shown to critically regulate leukocyte trafficking. Accumulating evidence indicates that the chronically relapsing inflammatory skin disease psoriasis represents a T cell-mediated disease. Thus, the understanding of the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics. Here results of recent studies associating chemokines with a psoriatic phenotype and delineating their role in the recruitment of memory T cells to the skin are discussed.

PMID:
15180470
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Bentham Science Publishers Ltd.
    Loading ...
    Write to the Help Desk