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J Bacteriol. 2004 Jun;186(12):4030-3.

The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli.

Author information

  • 1Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia.

Abstract

Cytochrome c biogenesis in Escherichia coli is a complex process requiring at least eight genes (ccmABCDEFGH). One of these genes, ccmG, encodes a thioredoxin-like protein with unusually specific redox activity. Here, we investigate the basis for CcmG function and demonstrate the importance of acidic residues surrounding the redox-active center.

PMID:
15175318
[PubMed - indexed for MEDLINE]
PMCID:
PMC419958
Free PMC Article

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