OBJECTIVE:

To evaluate the proposed link between the administration of the measles, mumps, and rubella (MMR) vaccine and the development of autism.

DATA SOURCES:

A literature search utilizing MEDLINE (1966-November 2003), with the key terms measles, mumps, rubella, and autism, was conducted. Review of the references listed in the articles identified was also performed.

DATA SYNTHESIS:

Ten articles that specifically evaluated the possible relationship between the MMR vaccine and autism were identified. Review articles, commentaries, and evaluations of a link between gastrointestinal symptoms in autistic children and MMR immunization were excluded.

CONCLUSIONS:

Based upon the current literature, it appears that there is no relationship between MMR vaccination and the development of autism.