Hum Immunol. 2004 May;65(5):500-6.

Cytomegalovirus (CMV)-specific cellular immune responses.

Source

Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.

Abstract

A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of the current strategies to identify CMV-specific T cells are centered on the assessment of the functions of memory T cells including their ability to mediate effector function, to proliferate or to secrete cytokines following antigen-specific stimulation. The investigation of these functions has allowed the characterization of the CMV-specific T-cell responses that are present during different phases of the infection. Furthermore, it has also been shown that the combination of virus-specific CD4 and CD8 T-cell responses are critical components of the immune response in the control of virus replication.

PMID:: 15172450; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Cytomegalovirus Infections - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Analyzing T-cell responses to cytomegalovirus by cytokine flow cytometry. [Hum Immunol. 2004]
Review Analyzing T-cell responses to cytomegalovirus by cytokine flow cytometry.
Maecker HT, Maino VC. Hum Immunol. 2004 May; 65(5):493-9.
Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children. [J Immunol. 2004]
Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children.
Tu W, Chen S, Sharp M, Dekker C, Manganello AM, Tongson EC, Maecker HT, Holmes TH, Wang Z, Kemble G, et al. J Immunol. 2004 Mar 1; 172(5):3260-7.
Review CD8(+) T-cell immunity to cytomegalovirus. [Hum Immunol. 2004]
Review CD8(+) T-cell immunity to cytomegalovirus.
Moss P, Khan N. Hum Immunol. 2004 May; 65(5):456-64.
Monitoring cytomegalovirus IE-1 and pp65-specific CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation may identify patients at risk for recurrent CMV reactivations. [Cytometry B Clin Cytom. 2008]
Monitoring cytomegalovirus IE-1 and pp65-specific CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation may identify patients at risk for recurrent CMV reactivations.
Gratama JW, Brooimans RA, van der Holt B, Sintnicolaas K, van Doornum G, Niesters HG, Löwenberg B, Cornelissen JJ. Cytometry B Clin Cytom. 2008 Jul; 74(4):211-20.
Review Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants. [Biol Blood Marrow Transplant. ...]
Review Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants.
Lacey SF, Diamond DJ, Zaia JA. Biol Blood Marrow Transplant. 2004 Jul; 10(7):433-47.

See reviews... See all...

Cited by 6 PubMed Central articles

Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets. [Immun Ageing. 2011]
Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets.
Litjens NH, de Wit EA, Betjes MG. Immun Ageing. 2011 Jan 8; 8(1):2. Epub 2011 Jan 8.
Human cytomegalovirus UL144 is associated with viremia and infant development sequelae in congenital infection. [J Clin Microbiol. 2010]
Human cytomegalovirus UL144 is associated with viremia and infant development sequelae in congenital infection.
Waters A, Hassan J, De Gascun C, Kissoon G, Knowles S, Molloy E, Connell J, Hall WW. J Clin Microbiol. 2010 Nov; 48(11):3956-62. Epub 2010 Sep 1.
Age-dependent association between low frequency of CD27/CD28 expression on pp65 CD8+ T cells and cytomegalovirus replication after transplantation. [Clin Vaccine Immunol. 2009]
Age-dependent association between low frequency of CD27/CD28 expression on pp65 CD8+ T cells and cytomegalovirus replication after transplantation.
Cantisán S, Torre-Cisneros J, Lara R, Rodríguez-Benot A, Santos F, Gutiérrez-Aroca J, Gayoso I, González-Padilla M, Casal M, Rivero A, et al. Clin Vaccine Immunol. 2009 Oct; 16(10):1429-38. Epub 2009 Aug 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cytomegalovirus (CMV)-specific cellular immune responses.
Cytomegalovirus (CMV)-specific cellular immune responses.
Hum Immunol. 2004 May ;65(5):500-6.

PubMed
Ferritin: a cytoprotective antioxidant strategem of endothelium.
Ferritin: a cytoprotective antioxidant strategem of endothelium.
J Biol Chem. 1992 Sep 5 ;267(25):18148-53.

PubMed
Analyzing T-cell responses to cytomegalovirus by cytokine flow cytometry.
Analyzing T-cell responses to cytomegalovirus by cytokine flow cytometry.
Hum Immunol. 2004 May ;65(5):493-9.

PubMed
Clinical validity of measuring time difference between onset of mitral inflow an...
Clinical validity of measuring time difference between onset of mitral inflow and onset of early diastolic mitral annulus velocity in the evaluation of left ventricular diastolic function.
J Am Coll Cardiol. 2004 Jun 2 ;43(11):2097-101.

PubMed
Prior convictions: Bayesian approaches to the analysis and interpretation of cli...
Prior convictions: Bayesian approaches to the analysis and interpretation of clinical megatrials.
J Am Coll Cardiol. 2004 Jun 2 ;43(11):1929-39.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Cytomegalovirus (CMV)-specific cellular immune responses.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 6 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information