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Medicina (Kaunas). 2004;40(5):419-22.

[Proinflammatory cytokine interleukin-17 and its role in pathogenesis of rheumatoid arthritis].

[Article in Lithuanian]

Author information

  • 1Institute of Experimental and Clinical Medicine, Vilnius University, Zygimantu 9, 2600 Vilnius, Lithuania. laima.leonaviciene@ekmi.vu.lt

Abstract

This is a review concerning the role of interleukin-17, a proinflammatory cytokine, produced by activated memory CD4+ T cells, in pathogenesis of rheumatoid arthritis. As interleukin-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. Interleukin-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

PMID:
15170409
[PubMed - indexed for MEDLINE]
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