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Am J Obstet Gynecol. 2004 May;190(5):1438-9.

Glyburide for the treatment of gestational diabetes.

Author information

  • 1Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida, USA.

Abstract

OBJECTIVE:

This study was undertaken to evaluate the effectiveness of glyburide in patients with gestational diabetes who failed diet therapy.

METHODS:

Patients who were beyond the first trimester and who failed to achieve satisfactory glucose control with diet therapy were treated with glyburide, at a starting dose of 2.5 mg daily. The dose was increased in increments to a maximum of 20 mg/day. The main treatment outcome was achievement of satisfactory glucose control, defined as a mean plasma fasting glucose 90 mg % or less and mean 1-hour postprandial plasma glucose determinations 135 mg % or less. Patients who failed to achieve satisfactory control were treated with twice-daily doses of insulin.

RESULTS:

During the period July 2001 through December 2002, we managed 197 patients with gestational diabetes. One-hundred twenty-four patients responded to diet alone; 73 were treated with glyburide. Of the 73 patients, 59 (81%, 95% CI 76.4-85.6) achieved satisfactory glucose control with glyburide; 44 women required 7.5 mg/day or less. Eleven of the 59 women (19%) had macrosomic infants. Eight patients (11%) experienced noticeable side effects related to glyburide; only 1 patient discontinued treatment.

CONCLUSION:

Approximately 80% of patients with gestational diabetes who fail to respond to diet therapy can be treated effectively with glyburide.

PMID:
15167862
[PubMed - indexed for MEDLINE]
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