Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genetics. 2004 May;167(1):513-22.

Mutators in space: the dynamics of high-mutability clones in a two-patch model.

Author information

  • 1Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom. emmatravis@cantab.net

Abstract

Clones of bacteria possessing high-mutability rates (or mutators) are being observed in an increasing number of species. In a constant environment most mutations are deleterious, and hence the spontaneous mutation rate is generally low. However, mutators may play an important role in the adaptation of organisms to changing environments. To date, theoretical work has focused on temporal variability in the environment, implicitly assuming that environmental conditions are constant through space. Here, we develop a two-patch model to investigate how spatiotemporal environmental variability and dispersal might influence mutator dynamics. Environmental conditions in each patch fluctuate between two states; the rate of fluctuation varies in each patch at differing phase angles. We find that at low and intermediate rates of fluctuation, an increase in dispersal results in a decrease in the density of mutators. However, at high rates of environmental change, dispersal causes an increase in mutator density. For all frequencies of environmental fluctuation these trends are enhanced as the phase angle approaches 180 degrees. We argue that future work, both empirical and theoretical, is needed to improve our understanding of how spatiotemporal variability impacts on mutator densities and dynamics.

PMID:
15166173
[PubMed - indexed for MEDLINE]
PMCID:
PMC1470850
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk