Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Microbiol. 2004 Jun;12(6):296-300.

Invasin and beyond: regulation of Yersinia virulence by RovA.

Author information

  • 1Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8230, St. Louis, MO 63110, USA.

Abstract

RovA, a member of the MarR/SlyA family of winged-helix transcription factors, regulates expression of invasin, the major adhesion and invasion factor in Yersinia enterocolitica and Yersinia pseudotuberculosis. Disruption of rovA increases the LD(50) of the organism when inoculated using the oral route. However, when administered by intraperitoneal injection only a slight difference in LD(50) between mutant and wild-type organisms is apparent. The study of RovA and the genes it regulates provides a unique opportunity to gain insight into the initial stages of a Yersinia infection.

PMID:
15165608
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk