-
The DNA sequence and comparative analysis of human chromosome 10.
Deloukas P,
Earthrowl ME,
Grafham DV,
Rubenfield M,
French L,
Steward CA,
Sims SK,
Jones MC,
Searle S,
Scott C,
Howe K,
Hunt SE,
Andrews TD,
Gilbert JG,
Swarbreck D,
Ashurst JL,
Taylor A,
Battles J,
Bird CP,
Ainscough R,
Almeida JP,
Ashwell RI,
Ambrose KD,
Babbage AK,
Bagguley CL,
Bailey J,
Banerjee R,
Bates K,
Beasley H,
Bray-Allen S,
Brown AJ,
Brown JY,
Burford DC,
Burrill W,
Burton J,
Cahill P,
Camire D,
Carter NP,
Chapman JC,
Clark SY,
Clarke G,
Clee CM,
Clegg S,
Corby N,
Coulson A,
Dhami P,
Dutta I,
Dunn M,
Faulkner L,
Frankish A,
Frankland JA,
Garner P,
Garnett J,
Gribble S,
Griffiths C,
Grocock R,
Gustafson E,
Hammond S,
Harley JL,
Hart E,
Heath PD,
Ho TP,
Hopkins B,
Horne J,
Howden PJ,
Huckle E,
Hynds C,
Johnson C,
Johnson D,
Kana A,
Kay M,
Kimberley AM,
Kershaw JK,
Kokkinaki M,
Laird GK,
Lawlor S,
Lee HM,
Leongamornlert DA,
Laird G,
Lloyd C,
Lloyd DM,
Loveland J,
Lovell J,
McLaren S,
McLay KE,
McMurray A,
Mashreghi-Mohammadi M,
Matthews L,
Milne S,
Nickerson T,
Nguyen M,
Overton-Larty E,
Palmer SA,
Pearce AV,
Peck AI,
Pelan S,
Phillimore B,
Porter K,
Rice CM,
Rogosin A,
Ross MT,
Sarafidou T,
Sehra HK,
Shownkeen R,
Skuce CD,
Smith M,
Standring L,
Sycamore N,
Tester J,
Thorpe A,
Torcasso W,
Tracey A,
Tromans A,
Tsolas J,
Wall M,
Walsh J,
Wang H,
Weinstock K,
West AP,
Willey DL,
Whitehead SL,
Wilming L,
Wray PW,
Young L,
Chen Y,
Lovering RC,
Moschonas NK,
Siebert R,
Fechtel K,
Bentley D,
Durbin R,
Hubbard T,
Doucette-Stamm L,
Beck S,
Smith DR,
Rogers J.
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. panos@sanger.ac.uk
The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome. Sequence annotation revealed 1,357 genes, of which 816 are protein coding, and 430 are pseudogenes. We observed widespread occurrence of overlapping coding genes (either strand) and identified 67 antisense transcripts. Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on the gene count on chromosome 10. Multispecies comparative analysis indicated that we can readily annotate the protein-coding genes with current resources. We estimate that over 95% of all coding exons were identified in this study. Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence.
PMID: 15164054 [PubMed - indexed for MEDLINE]
-
Cited by 6 PubMed Central articles
-
Current awareness on comparative and functional genomics.
.
Comp Funct Genomics. 2004; 5(8):658-69.
[Comp Funct Genomics. 2004]
-
Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.
Nejentsev S, Smink LJ, Smyth D, Bailey R, Lowe CE, Payne F, Masters J, Godfrey L, Lam A, Burren O, et al.
BMC Genet. 2007 May 17; 8:24. Epub 2007 May 17.
[BMC Genet. 2007]
-
ReviewEGASP: the human ENCODE Genome Annotation Assessment Project.
Guigó R, Flicek P, Abril JF, Reymond A, Lagarde J, Denoeud F, Antonarakis S, Ashburner M, Bajic VB, Birney E, et al.
Genome Biol. 2006; 7 Suppl 1:S2.1-31. Epub 2006 Aug 7.
[Genome Biol. 2006]
- » See all...