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J Virol. 2004 Jun;78(12):6688-91.

Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus.

Author information

  • 1Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, 225 Warren Streeet, Newark, NJ 07101-1709, USA.

Abstract

Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.

PMID:
15163760
[PubMed - indexed for MEDLINE]
PMCID:
PMC416537
Free PMC Article
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