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J Antimicrob Chemother. 2004 Jul;54(1):86-9. Epub 2004 May 26.

Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm.

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  • 1Institute of Dental Sciences and Department of Prosthodontics, Faculty of Dentistry, Hebrew University-Hadassah, PO Box 12272, Jerusalem, 91120, Israel. dorons@cc.huji.ac.il



Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria.


In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus.


The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05).


Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus.

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