Cell. 2004 May 28;117(5):558-9.

Class II MHC: sweetening the peptide only diet?

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Division of Cell Biology and Immunology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom.

Abstract

MHC molecules typically bind peptides to create ligands for the T cell antigen receptor. In this issue of Cell, report an unexpected association of class II MHC molecules with processed zwitterionic polysaccharides from pathogenic bacteria. The complexes appear to modulate the T cell dependent pathology of abscess formation.

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Polysaccharide processing and presentation by the MHCII pathway. [Cell. 2004]
Polysaccharide processing and presentation by the MHCII pathway.Cobb BA, Wang Q, Tzianabos AO, Kasper DL. Cell. 2004 May 28; 117(5):677-87.

PMID:: 15163404; [PubMed - indexed for MEDLINE]

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